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The long-term goals of our research program are to identify the molecular mechanisms and neural circuitry underlying antidepressant treatment response or resistance and ultimately to identify novel treatments, determine whether patients will respond to treatments, and develop personalized treatment strategies. To address this question, we study depression and anxiety in mouse models that offer an appropriate framework to assess treatment resistance with face, construct, and predictive validity. For example, we group mice engineered to display features of depression and anxiety by their behavioral response to treatment interventions. Gene expression profiles in selected brain regions that we define as critical for mediating an antidepressant response, such as the dentate gyrus, are then compared between responders and non-responders to treatment
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