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Our laboratory uses a range of biomedical research tools including molecular biology, protein chemistry, crystallography, and molecular modeling to pursue the development of drugs for treatment of human diseases including HIV/AIDS. Students will participate in efforts to understand the structure and function of HIV enzymes reverse transcriptase and integrase, and how these key elements of the AIDS virus interact with and respond to small molecules that can block biochemical and virological function. Efforts also include studies of how the proteins of HIV interact in the process of virus assembly and maturation.
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